SRSMC UMR 7565


Partenaires

CNRS


Rechercher

Sur ce site

Sur le Web du CNRS


Accueil > Pages Personnelles

Tarek Mounir


Director of Research (DR1) CNRS, UMR 7565, CNRS-University of Lorraine, France

Directeur de Recherche 1ère Classe, CNRS
Equipe de Théorie, Modélisation et Simulations
UMR7565 CNRS – Université de Lorraine, “Structure et Réactivité des Systèmes Moléculaires Complexes’ 



Membre du conseil directoire du Laboratoire International Associé EBAM
’[Applications des Impulsions Electriques en Biologie et Médecine->http://lea-ebam.cnrs.fr/]’


Directeur Adjoint de l’UMR 7565


Contact : mounir.tarek@univ-lorraine.fr
Tel :+33 (0) 3-72-74-52 74


Équipe TMS
UMR CNRS 7565 Université de Lorraine, FST
Boulevard des Aiguillettes, BP 239
54506 Vandœuvre-lès-Nancy Cedex,France

 
 


TRAINING AND EDUCATION


Research Positions :
• 2001-2002 : Poste Rouge CNRS, UMR 7565, CNRS-University of Lorraine, France
• 1997-2001 : Research Associate, National Institute of Standards and Technology, Gaithersburg, USA
Post-doctoral Training :
• 1994-1997 : Postdoctoral research fellow, Center for Molecular Modeling, Pennsylvania University, USA 
PhD Fellowship :
• 1991-1992 : CEA, Centre d’Etudes Nucléaires de Saclay, France
Degrees :
• 2009 : Habilitation, University of Lorraine Nancy, France
• 1994 : Doctor in Physics, Université Paris VII, Paris, France
• 1991 : M.Sc. in Physics Université de Paris VII, France


RESEARCH FOCUS

 Molecular Modelling of membranes and associated proteins-Ion Channels


PREVIOUS PROFESSIONAL POSITIONS AND APPOINTMENTS 

• 2015- Present : Director of Research (DR1) CNRS, UMR 7565, CNRS-University of Lorraine, France
• 2009- Present : Director of Research (DR2) CNRS, UMR 7565, CNRS-University of Lorraine, France
• 2002- 2009  : Researcher (CR1) CNRS, UMR 7565, CNRS-University of Lorraine, France


MISCELANEOUS


• 2005 - 2013 - Users Committee of the CINES Super Computer Center, President
• 2007-Present - ERASMUS Program, Physical Sciences – Université de Lorraine, Coordinator
• 2008-Present - Steering committee of the Doctoral school “SESAMES”, Member
• 2010-Present - Scientific Management Committee of the Laboratoire Européen Associé EBAM, Member
• 2012-Present - Management Committee of the COST action, EP4Bio2Med, Founding Member, Member
• 2014-Present - Vice chair, Deputy director of the SRSMC CNRS Unit.


 


RESEARCH INTEREST


Simulation of model membranes and membrane bound species is in biophysics a frontier area of research seething with excitements and challenges. The availability of all the ingredients to investigate membranes, in-silico, opens new perspectives particularly in the biological front. The aim of my research is to take computer simulations to an extra level, where manipulation of molecular nano-objects in-silico, by reproducing realistic mechanisms, sheds light onto challenging multidisciplinary problems.


TOPICS

  •  Electroporation of cell membranes (drug and gene delivery, electroshock healing, antibacterial treatment)....
  •  Transport through voltage-gated potassium ion channels (ion conduction and selectivity, regulation, mutations, chanellopathies)
  •  Action of synthetic peptides on membranes (antibacterial action)
  •  Interaction of carbon nanostructures with membranes and membrane proteins.
  •  Membrane Oxidation, Mecanisms.
  •  Development of Coarse grained force fields for biomolecular simulation

PUBLICATIONS

 

2015

Cournia, Z., Allen, T. W., Andricioaei, I., Antonny, B., Baum, D., Brannigan, G., Buchete, N. - V., Deckman, J. T., Delemotte, L., Val, C. del, Friedman, R., Gkeka, P., Hege, H. - C., Hénin, J., Kasimova, M. A., Kolocouris, A., Klein, M. L., Khalid, S., Lemieux, M. J., Lindow, N., Roy, M., Selent, J., Tarek, M., Tofoleanu, F., Vanni, S., Urban, S., Wales, D. J., Smith, J. C., & Bondar, A. - N. (2015). Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory. J Membrane Biol, 248(4), 611–640.
toggle visibility
Delemotte, L., Kasimova, M. A., Klein, M. L., Tarek, M., & Carnevale, V. (2015). Free-energy landscape of ion-channel voltage-sensor–domain activation. PNAS, 112(1), 124–129.
toggle visibility
Kasimova, M. A., Zaydman, M. A., Cui, J., & Tarek, M. (2015). PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6. Scientific Reports, 5, 7474.
toggle visibility

2014

Amarouch, M. - Y., Kasimova, M. A., Tarek, M., & Abriel, H. (2014). Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies. Channels, 8(5), 414–420.
toggle visibility
Casciola, M., Bonhenry, D., Liberti, M., Apollonio, F., & Tarek, M. (2014). A Molecular Dynamic Study of Cholesterol Rich Lipid Membranes: Comparison of Electroporation Protocols. Bioelectrochemistry, 100, 11–17.
toggle visibility
Conti Nibali, V., D’Angelo, G., Paciaroni, A., Tobias, D. J., & Tarek, M. (2014). On the Coupling between the Collective Dynamics of Proteins and Their Hydration Water. J. Phys. Chem. Lett., 5(7), 1181–1186.
toggle visibility
Dehez, F., Delemotte, L., Kramar, P., Miklavčič, D., & Tarek, M. (2014). Evidence of Conducting Hydrophobic Nanopores Across Membranes in Response to an Electric Field. J. Phys. Chem. C, 118(13), 6752–6757.
toggle visibility
Garrec, J., Monari, A., Assfeld, X., Mir, L. M., & Tarek, M. (2014). Lipid Peroxidation in Membranes: The Peroxyl Radical Does Not “Float”. J. Phys. Chem. Lett., 5(10), 1653–1658.
toggle visibility
Kasimova, M. A., Tarek, M., Shaytan, A. K., Shaitan, K. V., & Delemotte, L. (2014). Voltage-gated ion channel modulation by lipids: Insights from molecular dynamics simulations. Biochimica et Biophysica Acta (BBA) – Biomembranes, 1838(5), 1322–1331.
toggle visibility
Polak, A., Tarek, M., Tomšič, M., Valant, J., Poklar Ulrih, N., Jamnik, A., Kramar, P., & Miklavčič, D. (2014). Structural Properties of Archaeal Lipid Bilayers: Small-Angle X-ray Scattering and Molecular Dynamics Simulation Study. Langmuir, 30(28), 8308–8315.
toggle visibility
Polak, A., Tarek, M., Tomšič, M., Valant, J., Ulrih, N. P., Jamnik, A., Kramar, P., & Miklavčič, D. (2014). Electroporation of archaeal lipid membranes using MD simulations. Bioelectrochemistry, 100, 18–26.
toggle visibility
Polak, A., Velikonja, A., Kramar, P., Tarek, M., & Miklavčič, D. (2014). Electroporation Threshold of POPC Lipid Bilayers with Incorporated Polyoxyethylene Glycol (C12E8). J. Phys. Chem. B, 119(1), 192–200.
toggle visibility
Salomone, F., Breton, M., Leray, I., Cardarelli, F., Boccardi, C., Bonhenry, D., Tarek, M., Mir, L. M., & Beltram, F. (2014). High-Yield Nontoxic Gene Transfer through Conjugation of the CM18-Tat11 Chimeric Peptide with Nanosecond Electric Pulses. Mol. Pharmaceutics, 11(7), 2466–2474.
toggle visibility
Tarek, M. (2014). Prerequisites to proton transport in the bacterial ClC-ec1 Cl−/H+ exchanger. PNAS, 111(5), 1668–1669.
toggle visibility
Zaydman, M. A., Kasimova, M. A., McFarland, K., Beller, Z., Hou, P., Kinser, H. E., Liang, H., Zhang, G., Shi, J., Tarek, M., & Cui, J. (2014). Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel. eLife Sciences, 3, e03606.
toggle visibility

2013

Abriel, H., de Lange, E., Kucera, J. P., Loussouarn, G., & Tarek, M. (2013). Computational tools to investigate genetic cardiac channelopathies. Front Physiol, 4, 390.
toggle visibility
Bonhenry, D., Tarek, M., & Dehez, F. (2013). Effects of Phospholipid Composition on the Transfer of a Small Cationic Peptide Across a Model Biological Membrane. J. Chem. Theory Comput., 9(12), 5675–5684.
toggle visibility
Lacerda, L., Ali-Boucetta, H., Kraszewski, S., Tarek, M., Prato, M., Ramseyer, C., Kostarelos, K., & Bianco, A. (2013). How do functionalized carbon nanotubes land on, bind to and pierce through model and plasma membranes. Nanoscale, 5(21), 10242–10250.
toggle visibility
Paciaroni, A., Conti Nibali, V., Orecchini, A., Petrillo, C., Haertlein, M., Moulin, M., Tarek, M., D’Angelo, G., & Sacchetti, F. (2013). Vibrational excitations of proteins and their hydration water in the far-infrared range. Chemical Physics, 424, 80–83.
toggle visibility
Polak, A., Bonhenry, D., Dehez, F., Kramar, P., Miklavčič, D., & Tarek, M. (2013). On the electroporation thresholds of lipid bilayers: molecular dynamics simulation investigations. J. Membr. Biol., 246(11), 843–850.
toggle visibility
Tarek, M., & Delemotte, L. (2013). Omega Currents in Voltage-Gated Ion Channels: What Can We Learn from Uncovering the Voltage-Sensing Mechanism Using MD Simulations? Acc. Chem. Res., 46(12), 2755–2762.
toggle visibility

2012

Abderemane-Ali, F., Es-Salah-Lamoureux, Z., Delemotte, L., Kasimova, M. A., Labro, A. J., Snyders, D. J., Fedida, D., Tarek, M., Baro, I., & Loussouarn, G. (2012). Dual Effect of Phosphatidyl (4,5)-Bisphosphate PIP2 on Shaker K+ Channels. Journal of Biological Chemistry, 287(43), 36158–36167.
toggle visibility
Breton, M., Delemotte, L., Silve, A., Mir, L. M., & Tarek, M. (2012). Transport of siRNA through Lipid Membranes Driven by Nanosecond Electric Pulses: An Experimental and Computational Study. ., 134(34), 13938–13941.
toggle visibility
Delemotte, L., & Tarek, M. (2012). Molecular Dynamics Simulations of Lipid Membrane Electroporation. Journal of Membrane Biology, 245(9), 531–543.
toggle visibility
Delemotte, L., & Tarek, M. (2012). Molecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation. Front. Pharmacol., 3, 97.
toggle visibility
Kotnik, T., Kramar, P., Pucihar, G., Miklavcic, D., & Tarek, M. (2012). Cell membrane electroporation- Part 1: The phenomenon. IEEE Electrical Insulation Magazine, 28(5), 14–23.
toggle visibility
Kramar, P., Delemotte, L., Maček Lebar, A., Kotulska, M., Tarek, M., & Miklavčič, D. (2012). Molecular-Level Characterization of Lipid Membrane Electroporation using Linearly Rising Current. Journal of Membrane Biology, 245(10), 651–659.
toggle visibility
Kraszewski, S., Bianco, A., Tarek, M., & Ramseyer, C. (2012). Insertion of Short Amino-Functionalized Single-Walled Carbon Nanotubes into Phospholipid Bilayer Occurs by Passive Diffusion. PLoS ONE, 7(7), e40703.
toggle visibility
Loussouarn, G., & Tarek, M. (2012). Mechanisms of ion channels voltage-dependency: all about molecular sensors, gates, levers, locks, and grease. Frontiers in Pharmacology of Ion Channels and Channelopathies, , 174.
toggle visibility
Tarek, M., & Delemotte, L. (2012). L'eau dans les processus de transport cellulaires. Biofutur, (331), 37–39.
toggle visibility
Vargas, E., Yarov-Yarovoy, V., Khalili-Araghi, F., Catterall, W. A., Klein, M. L., Tarek, M., Lindahl, E., Schulten, K., Perozo, E., Bezanilla, F., & Roux, B. (2012). An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol, 140(6), 587–594.
toggle visibility

2011

Delemotte, L., Tarek, M., Klein, M. L., Amaral, C., & Treptow, W. (2011). Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations. Proceedings of the National Academy of Sciences, 108(15), 6109–6114.
toggle visibility
Kaye, M., Schmalzl, K., Nibali, V., Tarek, M., & Rheinstädter, M. (2011). Ethanol enhances collective dynamics of lipid membranes. Physical Review E, 83(5).
toggle visibility
Kraszewski, S., Tarek, M., & Ramseyer, C. (2011). Uptake and Translocation Mechanisms of Cationic Amino Derivatives Functionalized on Pristine C60 by Lipid Membranes: A Molecular Dynamics Simulation Study. ACS Nano, 5(11), 8571–8578.
toggle visibility

2010

Delemotte, L., Treptow, W., Klein, M. L., & Tarek, M. (2010). Effect of Sensor Domain Mutations on the Properties of Voltage-Gated Ion Channels: Molecular Dynamics Studies of the Potassium Channel Kv1.2. Biophysical Journal, 99(9), L72–L74.
toggle visibility
Khalfa, A., & Tarek, M. (2010). On the Antibacterial Action of Cyclic Peptides: Insights from Coarse-Grained MD Simulations. Journal of Physical Chemistry B, 114(8), 2676–2684.
toggle visibility
Kraszewski, S., Tarek, M., Treptow, W., & Ramseyer, C. (2010). Affinity of C-60 Neat Fullerenes with Membrane Proteins: A Computational Study on Potassium Channels. Acs Nano, 4(7), 4158–4164.
toggle visibility

Chapitres de Livre

2010

Tarek, M., & Delemotte, L. (2010). Electroporation of lipid membranes. In Advanced Electroporation Techniques in Biology and Medicine Andrei Pakhomov, Damijan Miklavcic and Marko Markov, Editors. (Taylor and Francis/CRC Press ed.).
toggle visibility
Tarek, M., & Delemotte, L. (2010). Water and Membranes: Insights from molecular dynamics simulations. In Water, The Forgotten Biological Molecule. Denis le Bihan and Hidenao Fukuyama, Editors. (Pan Stanford Publishing ed.).
toggle visibility